AZ1 rabbit pAb
Product Sizes
50UL
£ POA
ES6440-50UL
100UL
£ POA
ES6440-100UL
About this Product
- SKU:
- ES6440
- Additional Names:
- OAZ1; OAZ; Ornithine decarboxylase antizyme 1; ODC-Az
- Application:
- Western Blot, Immunohistochemistry, Immunofluorescence, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family; which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting; which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC); the key enzyme in polyamine biosynthesis; thus; completing the auto-regulatory circuit. This gene encodes antizyme 1; the first member of the antizyme family; that has broad tissue distribution; and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation; as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs; and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human OAZ1. AA range:14-63
- Isotype:
- IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
