IRP-1 (phospho Ser138) rabbit pAb
Product Sizes
50UL
£ POA
ES6389-50UL
100UL
£ POA
ES6389-100UL
About this Product
- SKU:
- ES6389
- Additional Names:
- ACO1; IREB1; Cytoplasmic aconitate hydratase; Aconitase; Citrate hydro-lyase; Ferritin repressor protein; Iron regulatory protein 1; IRP1; Iron-responsive element-binding protein 1; IRE-BP 1
- Application:
- Immunohistochemistry, Immunofluorescence, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- The protein encoded by this gene is a bifunctional; cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high; this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low; the protein binds to iron-responsive elements (IREs); which are stem-loop structures found in the 5' UTR of ferritin mRNA; and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE; it results in repression of translation of ferritin mRNA; and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human IREB1 around the phosphorylation site of Ser138. AA range:106-155
- Isotype:
- IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
