AF-4 rabbit pAb
Product Sizes
50UL
£ POA
ES6253-50UL
100UL
£ POA
ES6253-100UL
About this Product
- SKU:
- ES6253
- Additional Names:
- AFF1; AF4; FEL; MLLT2; PBM1; AF4/FMR2 family member 1; ALL1-fused gene from chromosome 4 protein; Protein AF-4; Protein FEL; Proto-oncogene AF4
- Application:
- Immunohistochemistry, Immunofluorescence, Western Blot, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- This gene encodes a member of the AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome family of proteins; which have been implicated in childhood lymphoblastic leukemia; Fragile X E site mental retardation; and ataxia. It is the prevalent mixed-lineage leukemia fusion gene associated with spontaneous acute lymphoblastic leukemia. Members of this family have three conserved domains: an N-terminal homology domain; an AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome domain; and a C-terminal homology domain. The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions. Through RNA interference screens; this gene has been shown to promote the expression of CD133; a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing results in mu
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human AF4. AA range:1-50
- Isotype:
- IgG
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
