MEK Kinase-4 rabbit pAb
Product Sizes
50UL
£ POA
ES6230-50UL
100UL
£ POA
ES6230-100UL
About this Product
- SKU:
- ES6230
- Additional Names:
- MAP3K4; KIAA0213; MAPKKK4; MEKK4; MTK1; Mitogen-activated protein kinase kinase kinase 4; MAP three kinase 1; MAPK/ERK kinase kinase 4; MEK kinase 4; MEKK 4
- Application:
- Immunohistochemistry, Immunofluorescence, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK); which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation; the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock; UV irradiation; wound stress; and inflammatory factors. This gene encodes a MAPKKK; the MEKK4 protein; also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways; but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human MAP3K4. AA range:1281-1330
- Isotype:
- IgG
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
