MDMX rabbit pAb
Product Sizes
50UL
£ POA
ES6214-50UL
100UL
£ POA
ES6214-100UL
About this Product
- SKU:
- ES6214
- Additional Names:
- MDM4; MDMX; Protein Mdm4; Double minute 4 protein; Mdm2-like p53-binding protein; Protein Mdmx; p53-binding protein Mdm4
- Application:
- Western Blot, Immunohistochemistry, Immunofluorescence, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus; and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity; and have been shown to be overexpressed in a variety of human cancers. However; unlike MDM2 which degrades p53; this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain; and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53; while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq; Feb 2011];
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human MDM4. AA range:336-385
- Isotype:
- IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
