MC1-R rabbit pAb
Product Sizes
50UL
£ POA
ES6201-50UL
100UL
£ POA
ES6201-100UL
About this Product
- SKU:
- ES6201
- Additional Names:
- MC1R; MSHR; Melanocyte-stimulating hormone receptor; MSH-R; Melanocortin receptor 1; MC1-R
- Application:
- Western Blot, ELISA, Immunohistochemistry
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein; a seven pass transmembrane G protein coupled receptor; controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production; which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color; providing evidence that this gene is an important component in de
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human MSHR. AA range:268-317
- Isotype:
- IgG
- Reactivities:
- Human, Rat, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
