Factor I rabbit pAb
Product Sizes
50UL
£ POA
ES5825-50UL
100UL
£ POA
ES5825-100UL
About this Product
- SKU:
- ES5825
- Additional Names:
- CFI; IF; Complement factor I; C3B/C4B inactivator
- Application:
- Western Blot, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains; which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b; and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency; an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uremic syndrome; a disease characterized by acute renal failure; microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immune deposits and age-related macular degeneration are other conditions associated with mutations of this gene. [provided by Ref
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human CFI. AA range:441-490
- Isotype:
- IgG
- Reactivities:
- Human, Rat, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
