Lck BP-1 (phospho Tyr378) rabbit pAb
Product Sizes
50UL
£ POA
ES5722-50UL
100UL
£ POA
ES5722-100UL
About this Product
- SKU:
- ES5722
- Additional Names:
- HCLS1; HS1; Hematopoietic lineage cell-specific protein; Hematopoietic cell-specific LYN substrate 1; LckBP1; p75
- Application:
- Western Blot, ELISA, Immunohistochemistry
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- developmental stage:Expressed in early stage of myeloid and erythroid differentiation.;function:Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression.;PTM:Phosphorylated by LYN; rapidly after cross-linking of surface IgM on B-cells.;similarity:Contains 1 SH3 domain.;similarity:Contains 4 cortactin repeats.;subunit:Associates with the SH2 and SH3 domains of LCK. Binding to he LCK SH3 domain occurs constitutively; while binding to the LCK SH2 domain occurs only upon TCR stimulation. A similar binding pattern was observed with LYN; but not with FYN in which the FYN SH2 region associates upon TCR stimulation but the FYN SH3 region does not associate regardless of TCR stimulation. Directly associates with HAX1; through binding to its C-terminal region. Interacts with HS1BP3.;tissue specificity:Expressed only in tissues and cells of hematopoietic origin.;
- Immunogen:
- Synthesized phospho-peptide around the phosphorylation site of human Lck BP-1 (phospho Tyr378)
- Isotype:
- IgG
- Reactivities:
- Human, Rat, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
