Abl1/2 (phospho Tyr393/439) rabbit pAb
Product Sizes
50UL
£ POA
ES5407-50UL
100UL
£ POA
ES5407-100UL
About this Product
- SKU:
- ES5407
- Additional Names:
- ABL1; ABL; JTK7; Tyrosine-protein kinase ABL1; Abelson murine leukemia viral oncogene homolog 1; Abelson tyrosine-protein kinase 1; Proto-oncogene c-Abl; p150; ABL2; ABLL; ARG; Abelson tyrosine-protein kinase 2; Abelson murine leukemia vira
- Application:
- Western Blot, Immunohistochemistry, Immunofluorescence, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes; including cell division; adhesion; differentiation; and response to stress. The activity of the protein is negatively regulated by its SH3 domain; whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation; suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias; most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants; which contain alternative first exons that are spliced to the remaining common exons. [pr
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human Abl around the phosphorylation site of Tyr393/412. AA range:406-455
- Isotype:
- IgG
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Type:
- Antibodies: Polyclonal Antibody
