Dematin (phospho Ser403) rabbit pAb
Product Sizes
50UL
£ POA
ES5124-50UL
100UL
£ POA
ES5124-100UL
About this Product
- SKU:
- ES5124
- Additional Names:
- EPB49; DMT; Dematin; Erythrocyte membrane protein band 4.9
- Application:
- Western Blot, Immunohistochemistry, Immunofluorescence, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- The protein encoded by this gene is an actin binding and bundling protein that plays a structural role in erythrocytes; by stabilizing and attaching the spectrin/actin cytoskeleton to the erythrocyte membrane in a phosphorylation-dependent manner. This protein contains a core domain in the N-terminus; and a headpiece domain in the C-terminus that binds F-actin. When purified from erythrocytes; this protein exists as a trimer composed of two 48 kDa polypeptides and a 52 kDa polypeptide. The different subunits arise from alternative splicing in the 3' coding region; where the headpiece domain is located. Disruption of this gene has been correlated with the autosomal dominant Marie Unna hereditary hypotrichosis disease; while loss of heterozygosity of this gene is thought to play a role in prostate cancer progression. Alternative splicing results in multiple transcript variants encoding di
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human Dematin around the phosphorylation site of Ser403. AA range:356-405
- Isotype:
- IgG
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
