MKP-1 (phospho Ser359) rabbit pAb
Product Sizes
50UL
£ POA
ES5029-50UL
100UL
£ POA
ES5029-100UL
About this Product
- SKU:
- ES5029
- Additional Names:
- DUSP1; CL100; MKP1; PTPN10; VH1; Dual specificity protein phosphatase 1; Dual specificity protein phosphatase hVH1; Mitogen-activated protein kinase phosphatase 1; MAP kinase phosphatase 1; MKP-1; Protein-tyrosine phosphatase CL100
- Application:
- Immunohistochemistry, Immunofluorescence, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family; and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity; and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore; it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus; DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferati
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human MKP1 around the phosphorylation site of Ser359. AA range:318-367
- Isotype:
- IgG
- Reactivities:
- Human, Rat, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
