COL4A3 rabbit pAb
Product Sizes
50UL
£ POA
ES4737-50UL
100UL
£ POA
ES4737-100UL
About this Product
- SKU:
- ES4737
- Additional Names:
- COL4A3; Collagen alpha-3(IV) chain; Goodpasture antigen
- Application:
- Immunohistochemistry, Immunofluorescence, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Type IV collagen; the major structural component of basement membranes; is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes; alpha 1 through alpha 6; each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome; autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal r
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human Collagen IV alpha3. AA range:801-850
- Isotype:
- IgG
- Reactivities:
- Human, Rat, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
