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Antibodies

4E-BP1 (phospho Thr69) rabbit pAb

Product Sizes
50UL
£ POA
ES4385-50UL
100UL
£ POA
ES4385-100UL
About this Product
SKU:
ES4385
Additional Names:
EIF4EBP1; Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I
Application:
Western Blot, Immunohistochemistry, Immunofluorescence, ELISA
Clonality:
Polyclonal
Concentration:
1 mg/ml
Extra Details:
EIF4EBP1 encodes one member of a family of translation repressor proteins. The eukaryotic translation initiation factor 4E binding protein 1 directly interacts with eukaryotic translation initiation factor 4E (eIF4E); which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling; resulting in its dissociation from eIF4E and activation of mRNA translation.
Immunogen:
The antiserum was produced against synthesized peptide derived from mouse 4E-BP1 around the phosphorylation site of Thr69. AA range:35-84
Isotype:
IgG
Reactivities:
Mouse, Rat
Shipping Conditions:
Blue Ice
Source:
Rabbit
Storage Conditions:
-20[o]C
Type:
Antibodies: Polyclonal Antibody
Immunohistochemical analysis of paraffin-embedded Human colon cancer. Antibody was diluted at 1:100(4° overnight). High-pressure and temperature Tris-EDTA;pH8.0 was used for antigen retrieval. Negetive contrl (right) obtaned from antibody was pre-absorbed by immunogen peptide.
Enzyme-Linked Immunosorbent Assay (Phospho-ELISA) for Immunogen Phosphopeptide (Phospho-left) and Non-Phosphopeptide (Phospho-right); using 4E-BP1 (Phospho-Thr69) Antibody
Immunohistochemistry analysis of paraffin-embedded human brain carcinoma; using 4E-BP1 (Phospho-Thr69) Antibody. The picture on the right is blocked with the phospho peptide.
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