Acetyl Lys proteins rabbit pAb
Product Sizes
50UL
£ POA
ES4384-50UL
100UL
£ POA
ES4384-100UL
About this Product
- SKU:
- ES4384
- Application:
- Western Blot, Immunohistochemistry, Immunofluorescence, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Acetylation of lysine; like phosphorylation of serine; threonine or tyrosine; is an important reversible modification controlling protein activity. The conserved amino-terminal domains of the four core histones (H2A; H2B; H3; and H4) contain lysines that are acetylated by histone acetyltransferases (HATs) and deacetylated by histone deacetylases (HDACs). Signaling resulting in acetylation/deacetylation of histones; transcription factors; and other proteins affects a diverse array of cellular processes including chromatin structure and gene activity; cell growth; differentiation; and apoptosis. Recent proteomic surveys suggest that acetylation of lysine residues may be a widespread and important form of posttranslational protein modification that affects thousands of proteins involved in control of cell cycle and metabolism; longevity; actin polymerization; and nuclear transport. The regulation of protein acetylation status is impaired in cancer and polyglutamine diseases; and HDACs have become promising targets for anti-cancer drugs currently in development.
- Immunogen:
- Synthesized acetyl-peptide derived from human acetylation Lys proteins.
- Isotype:
- IgG
- Reactivities:
- Human, Mouse, Rat, Non-human Primate, Plant
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
