Cryopyrin rabbit pAb
Product Sizes
50UL
£ POA
ES4112-50UL
100UL
£ POA
ES4112-100UL
About this Product
- SKU:
- ES4112
- Additional Names:
- NLRP3; C1orf7; CIAS1; NALP3; PYPAF1; NACHT; LRR and PYD domains-containing protein 3; Angiotensin/vasopressin receptor AII/AVP-like; Caterpiller protein 1.1CLR1.1; Cold autoinflammatory syndrome 1 protein; Cryopyrin; PYRIN-containing APAF1-like protein 1
- Application:
- Western Blot, Immunohistochemistry, Immunofluorescence, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- This gene encodes a pyrin-like protein containing a pyrin domain; a nucleotide-binding site (NBS) domain; and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC; which contains a caspase recruitment domain; and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling; and it plays a role in the regulation of inflammation; the immune response; and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS); Muckle-Wells syndrome (MWS); chronic infantile neurological cutaneous and articular (CINCA) syndrome; and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are s
- Immunogen:
- The antiserum was produced against synthesized peptide derived from the Internal region of human NLRP3. AA range:511-560
- Isotype:
- IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
