PTTG1/2/3 rabbit pAb
Product Sizes
50UL
£ POA
ES3282-50UL
100UL
£ POA
ES3282-100UL
About this Product
- SKU:
- ES3282
- Additional Names:
- PTTG1; EAP1; PTTG; TUTR1; Securin; Esp1-associated protein; Pituitary tumor-transforming gene 1 protein; Tumor-transforming protein 1; hPTTG
- Application:
- Western Blot, Immunohistochemistry, Immunofluorescence, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- The encoded protein is a homolog of yeast securin proteins; which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo; and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs; which are required for its transforming and tumorigenic activities; as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein; although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been fo
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human PTTG1. AA range:111-160
- Isotype:
- IgG
- Reactivities:
- Human, Rat, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
