PHLDA3 rabbit pAb
Product Sizes
50UL
£ POA
ES3194-50UL
100UL
£ POA
ES3194-100UL
About this Product
- SKU:
- ES3194
- Additional Names:
- PHLDA3; TIH1; Pleckstrin homology-like domain family A member 3; TDAG51/Ipl homolog 1
- Application:
- Western Blot, Immunohistochemistry, Immunofluorescence, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- domain:The PH domain binds phosphoinositides with a broad specificity. It competes with the PH domain of AKT1 and directly interferes with AKT1 binding to phosphatidylinositol 4;5-bisphosphate (PIP2) and phosphatidylinositol 3;4;5-triphosphate (PIP3); preventing AKT1 association to membrane lipids and subsequent activation of AKT1 signaling.;function:p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids; thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its directs transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May acts as a tumor suppressor.;induction:By p53/TP53; expression is directly activated by p53/TP53. p53/TP53 phosphorylation on 'Ser-15' is required to activate the PHLDA3 promoter.;miscellaneous:PHLDA3 genomic locus is frequently observed in primary lung cancers; suggesting a role in tumor suppression.;similarity:Belongs to the PHLDA3 family.;similarity:Contains 1 PH domain.;tissue specificity:Widely expressed with lowest expression in liver and spleen.;
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human PHLDA3. AA range:21-70
- Isotype:
- IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
