NUB1 rabbit pAb
Product Sizes
50UL
£ POA
ES2990-50UL
100UL
£ POA
ES2990-100UL
About this Product
- SKU:
- ES2990
- Additional Names:
- NUB1; NYREN18; NEDD8 ultimate buster 1; Negative regulator of ubiquitin-like proteins 1; Renal carcinoma antigen NY-REN-18
- Application:
- Western Blot, Immunohistochemistry, Immunofluorescence, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- This gene encodes a protein that functions as a negative regulator of NEDD8; a ubiquitin-like protein that conjugates with cullin family members in order to regulate vital biological events. The protein encoded by this gene regulates the NEDD8 conjugation system post-transcriptionally by recruiting NEDD8 and its conjugates to the proteasome for degradation. This protein interacts with the product of the AIPL1 gene; which is associated with Leber congenital amaurosis; an inherited retinopathy; and mutations in that gene can abolish interaction with this protein; which may contribute to the pathogenesis. This protein is also known to accumulate in Lewy bodies in Parkinson's disease and dementia with Lewy bodies; and in glial cytoplasmic inclusions in multiple system atrophy; with this abnormal accumulation being specific to alpha-synucleinopathy lesions. Alternative splici
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human NYREN18. AA range:566-615
- Isotype:
- IgG
- Reactivities:
- Human, Mouse, Non-human Primate
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
