KMT1B rabbit pAb
Product Sizes
50UL
£ POA
ES2678-50UL
100UL
£ POA
ES2678-100UL
About this Product
- SKU:
- ES2678
- Additional Names:
- SUV39H2; KMT1B; Histone-lysine N-methyltransferase SUV39H2; Histone H3-K9 methyltransferase 2; H3-K9-HMTase 2; Lysine N-methyltransferase 1B; Suppressor of variegation 3-9 homolog 2; Su(var)3-9 homolog 2
- Application:
- Western Blot, ELISA, Immunohistochemistry
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- catalytic activity:S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine.;domain:Although the SET domain contains the active site of enzymatic activity; both pre-SET and post-SET domains are required for methyltransferase activity. The SET domain also participates to stable binding to heterochromatin.;function:Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1; CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions; thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes; such as cell cycle regulation; transcriptional repression and regulation of telomere length. May participate in regulation of higher order chromatin organization during spermatogenesis.;similarity:Belongs to the histone-lysine methyltransferase family. Suvar3-9 subfamily.;similarity:Contains 1 chromo domain.;similarity:Contains 1 post-SET domain.;similarity:Contains 1 pre-SET domain.;similarity:Contains 1 SET domain.;subcellular location:Associates with centromeric constitutive heterochromatin.;subunit:Interacts with SMAD5.;
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human SUV39H2. AA range:111-160
- Isotype:
- IgG
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
