GIT1 rabbit pAb
Product Sizes
50UL
£ POA
ES2426-50UL
100UL
£ POA
ES2426-100UL
About this Product
- SKU:
- ES2426
- Additional Names:
- GIT1; ARF GTPase-activating protein GIT1; ARF GAP GIT1; Cool-associated and tyrosine-phosphorylated protein 1; CAT-1; CAT1; G protein-coupled receptor kinase-interactor 1; GRK-interacting protein 1
- Application:
- Western Blot, Immunohistochemistry, Immunofluorescence, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- domain:The paxillin-binding domain is masked in the full-length protein and is regulated by ARHGEF6.;function:GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking; adhesion and cytoskeletal organization. Increases the speed of cell migration; as well as the size and rate of formation of protrusions; possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine-phosphorylated paxillin in cytoplasmic complexes.;PTM:Phosphorylated on tyrosine residues by PTK2 and SRC in growing fibroblasts. Tyrosine-phosphorylation is increased following cell spreading on fibronectin; decreased in cells arrested in mitosis and increased in the ensuing G1 phase.;similarity:Contains 1 Arf-GAP domain.;similarity:Contains 3 ANK repeats.;subcellular location:Cycles between at least 3 distinct intracellular compartments; including focal adhesions; cytoplasmic complexes and membrane protrusions. During cell migration; when cells detach; moves from the adhesions into the cytoplasmic complexes towards the leading edge; while; when cells adhere; it is found in vinculin-containing adhesions. Recruitment to adhesions may be mediated by active tyrosine-phosphorylated paxillin.;subunit:Interacts with G protein-coupled receptor kinases: ADRBK1/GRK2; PPFIA1 and PPFIA4. Interacts with ARHGEF6/alpha-PIX; with ARHGEF7/beta-PIX; with PXN/paxillin and with PTK2/FAK (By similarity). Component of cytoplasmic complexes; which also contain PXN; ARHGEF6 and PAK1. Interacts with TGFB1I1.;
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human GIT1. AA range:561-610
- Isotype:
- IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Type:
- Antibodies: Polyclonal Antibody
