FRS2 rabbit pAb
Product Sizes
50UL
£ POA
ES2376-50UL
100UL
£ POA
ES2376-100UL
About this Product
- SKU:
- ES2376
- Additional Names:
- FRS2; Fibroblast growth factor receptor substrate 2; FGFR substrate 2; FGFR-signaling adaptor SNT; Suc1-associated neurotrophic factor target 1; SNT-1
- Application:
- Western Blot, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- function:Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.;PTM:Phosphorylated on tyrosine residues upon stimulation by NGF.;PTM:Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination.;sequence caution:Translated as stop.;similarity:Contains 1 IRS-type PTB domain.;subcellular location:Cytoplasmic; membrane-bound.;subunit:Part of a complex containing FRS2; GRB2 and SOS1. Part of a complex containing GRB2 and CBL. Binds RET (By similarity). Binds FGFR1; SUC1; NTRK1; NTRK2; NTRK3 and SRC. The tyrosine-phosphorylated protein binds the SH2 domains of GRB2 and PTPN11.;tissue specificity:Highly expressed in heart; brain; spleen; lung; liver; skeletal muscle; kidney and testis.;
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human FRS2. AA range:162-211
- Isotype:
- IgG
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
