Dok-3 rabbit pAb
Product Sizes
50UL
£ POA
ES2192-50UL
100UL
£ POA
ES2192-100UL
About this Product
- SKU:
- ES2192
- Additional Names:
- DOK3; Docking protein 3; Downstream of tyrosine kinase 3
- Application:
- Western Blot, Immunohistochemistry, Immunofluorescence, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- domain:PTB domain mediates receptor interaction.;function:DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL function.;PTM:Constitutively tyrosine-phosphorylated.;PTM:On IL2 stimulation; phosphorylated on C-terminal tyrosine residues possibly by Src kinases. Can also be phosphorylated by ABL kinase.;similarity:Belongs to the DOK family. Type A subfamily.;similarity:Contains 1 IRS-type PTB domain.;similarity:Contains 1 PH domain.;subunit:On tyrosine phosphorylation; interacts with CSK and INPP5D/SHIP1 via their SH2 domains. Both Tyr-381 and Tyr-398 are required for interaction with INPP5D. Only Tyr-381 is required for interaction with CSK. Binds ABL through the PTB domain and in a kinase-dependent manner. Does not interact with RasGAP.;tissue specificity:Expressed in spleen.;
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human DOK3. AA range:101-150
- Isotype:
- IgG
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
