DIO3 rabbit pAb
Product Sizes
50UL
£ POA
ES2173-50UL
100UL
£ POA
ES2173-100UL
About this Product
- SKU:
- ES2173
- Additional Names:
- DIO3; ITDI3; TXDI3; Type III iodothyronine deiodinase; 5DIII; DIOIII; Type 3 DI; Type-III 5'-deiodinase
- Application:
- Western Blot, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3;3';5-triiodothyronine (T3) to inactive metabolites; 3;3';5'-triiodothyronine (RT3) and 3;3'-diiodothyronine (T2); respectively. This enzyme is highly expressed in pregnant uterus; placenta; fetal and neonatal tissues; and thought to prevent premature exposure of developing fetal tissues to adult levels of thyroid hormones. It regulates circulating fetal thyroid hormone concentrations; and thus plays a critical role in mammalian development. Knockout mice lacking this gene exhibit abnormalities related to development and reproduction; and increased activity of this enzyme in infants with hemangiomas causes severe hypothyroidism. This protei
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human DIO3. AA range:17-66
- Isotype:
- IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
