Dbf4 rabbit pAb
Product Sizes
50UL
£ POA
ES2148-50UL
100UL
£ POA
ES2148-100UL
About this Product
- SKU:
- ES2148
- Additional Names:
- DBF4; ASK; DBF4A; ZDBF1; Protein DBF4 homolog A; Activator of S phase kinase; Chiffon homolog A; DBF4-type zinc finger-containing protein 1
- Application:
- Western Blot, Immunohistochemistry, Immunofluorescence, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- function:Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle.;induction:Induced in G1 phase at low level; increased during G1-S phase and remain high during S and G2-M phase.;PTM:Phosphorylated upon DNA damage; probably by ATM or ATR.;similarity:Contains 1 DBF4-type zinc finger.;similarity:Contains 2 BRCT domains.;subunit:Forms a complex with CDC7. Note that CDC7 forms distinct complex either with DBF4A or DBF4B. Such complexes are stable upon replication stress. Interacts with MEN1; MCM2; ORC2L; ORC4L and ORC6L.;tissue specificity:Highly expressed in testis and thymus. Expressed also in most cancer cells lines.;
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human DBF4. AA range:10-59
- Isotype:
- IgG
- Reactivities:
- Human, Mouse, Non-human Primate
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
