Cyclin L1 rabbit pAb
Product Sizes
50UL
£ POA
ES2087-50UL
100UL
£ POA
ES2087-100UL
About this Product
- SKU:
- ES2087
- Additional Names:
- CCNL1; BM-001; Cyclin-L1; Cyclin-L
- Application:
- Western Blot, Immunohistochemistry, Immunofluorescence, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- alternative products:Ccnl1 is an immediate-early gene with independently regulated isoforms;domain:Contains a RS region (arginine-serine dipeptide repeat) within the C-terminal domain which is the hallmark of the SR family of splicing factors. This region probably plays a role in protein-protein interactions.;function:Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Seems to be involved in the regulation of RNA polymerase II (pol II). Functions in association with cyclin-dependent kinases (CDKs) and has a role in the second step of splicing. May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC). Inhibited by the CDK-specific inhibitor p21.;miscellaneous:CCNL1 is amplified in several HNSCC. May play a critical role in the formation of loco-regional metastases and an unfavorable clinical outcome of HNSCC.;sequence caution:Probable cloning artifact.;similarity:Belongs to the cyclin family. Cyclin L subfamily.;subcellular location:More specifically found in nuclear intrachromatin granules clusters (IGC); also called nuclear speckles; which are storage compartments for nuclear proteins involved in mRNA processing.;subunit:Interacts with POLR2A via its hyperphosphorylated C-terminal domain (CTD) (By similarity). Interacts with CDC2L1 or CDC2L2; and SFRS2.;tissue specificity:Ubiquitous with higher level in thymus. Overexpression in primary tumors of head and neck squamous cell carcinomas (HNSCC).;
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human Cyclin L1. AA range:461-510
- Isotype:
- IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
