MeCP2 rabbit pAb
Product Sizes
50UL
£ POA
ES20671-50UL
100UL
£ POA
ES20671-100UL
About this Product
- SKU:
- ES20671
- Additional Names:
- Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2)
- Application:
- Western Blot
- Clonality:
- Polyclonal
- Extra Details:
- DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2; MBD1; MBD2; MBD3; and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins; with the exception of MBD3; is capable of binding specifically to methylated DNA. MECP2; MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members; MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells; but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome; a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. Alternative splicing results in multiple transcript variants encoding different isofor
- Immunogen:
- Synthetic Peptide of MeCP2 AA range: 313-363
- Isotype:
- IgG
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
