C163A rabbit pAb
Product Sizes
50UL
£ POA
ES20338-50UL
100UL
£ POA
ES20338-100UL
About this Product
- SKU:
- ES20338
- Application:
- Western Blot, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- caution:It is uncertain whether Met-1 or Met-6 is the initiator.;disease:The soluble form (sCD163) in plasma is a novel parameter in diseases affecting macrophage function and monocyte/macrophage load in the body. The concentration of sCD163 is probably reflecting the number of macrophages of the 'alternative macrophage activation' phenotype with a high CD163 expression playing a major role in dampening the inflammatory response and scavenging components of damaged cells. This has initiated a number of clinical studies for evaluation of sCD163 as a disease marker in inflammatory conditions e.g. infection; autoimmune disease; transplantation; atherosclerosis and cancer.;domain:The SRCR domain 3 mediates calcium-sensitive interaction with hemoglobin/haptoglobin complexes.;function:Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron; via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization; inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.;function:After shedding; the soluble form (sCD163) may play an anti-inflammatory role; and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.;induction:Induced by anti-inflammatory mediators such as glucocorticoids; IL6 and IL10; suppressed by proinflammatory mediators like lipopolysaccharide (LPS); Interferon gamma/IFNG; and tumor necrosis factor alpha.;miscellaneous:Intravenous lipopolysaccharide (LPS) produces a rapid rise of sCD163 in plasma of patient as it induces metalloproteinase-mediated shedding from monocytes surface. Long-term LPS infusion finally increases expression of the membrane-bound form on circulating monocytes.;PTM:A soluble form (sCD163) is produced by proteolytic shedding which can be induced by lipopolysaccharide; phorbol ester and Fc region of immunoglobulin gamma. This cleavage is dependent on protein kinase C and tyrosine kinases and can be blocked by protease inhibitors. The shedding is inhibited by the tissue inhibitor of metalloproteinase TIMP3; and thus probably induced by membrane-bound metalloproteinases ADAMs.;PTM:Phosphorylated.;similarity:Contains 9 SRCR domains.;subcellular location:Isoform 1 and isoform 2 show a lower surface expression when expressed in cells.;subunit:Interacts with CSNK2B.;tissue specificity:Expressed in monocytes and mature macrophages such as Kupffer cells in the liver; red pulp macrophages in the spleen; cortical macrophages in the thymus; resident bone marrow macrophages and meningeal macrophages of the central nervous system. Expressed also in blood. Isoform 1 is the lowest abundant in the blood. Isoform 2 is the lowest abundant in the liver and the spleen. Isoform 3 is the predominant isoform detected in the blood.;
- Immunogen:
- Synthesized peptide derived from human C163A
- Isotype:
- IgG
- Reactivities:
- Human, Rat, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
