IL23A rabbit pAb
Product Sizes
50UL
£ POA
ES20324-50UL
100UL
£ POA
ES20324-100UL
About this Product
- SKU:
- ES20324
- Additional Names:
- Interleukin-23 subunit alpha (IL-23 subunit alpha;IL-23-A;Interleukin-23 subunit p19;IL-23p19)
- Application:
- Western Blot, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- developmental stage:Expressed by newborns dendritic cells.;function:Associates with IL12B to form the IL-23 interleukin; an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R; activates the Jak-Stat signaling cascade; stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.;induction:Up-regulated by a wide array of pathogens and pathogen-products together with self-signals for danger or injury. Up-regulated in psoriatic dermal tissues; in dendritic cells of multiple sclerosis patients and in tumors.;similarity:Belongs to the IL-6 superfamily.;subcellular location:Secreted upon association with IL12B.;subunit:Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-23.;tissue specificity:Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level).;
- Immunogen:
- Synthesized peptide derived from human IL23A
- Isotype:
- IgG
- Reactivities:
- Human, Rat, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
