MDC rabbit pAb
Product Sizes
50UL
£ POA
ES20292-50UL
100UL
£ POA
ES20292-100UL
About this Product
- SKU:
- ES20292
- Additional Names:
- C-C motif chemokine 22 (CC chemokine STCP-1;MDC(1-69);Macrophage-derived chemokine;Small-inducible cytokine A22;Stimulated T-cell chemotactic protein 1) [Cleaved into: MDC(3-69); MDC(5-69); MDC(7-69)]
- Application:
- Western Blot, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- function:May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes; dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils; eosinophils; and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69); MDC(5-69) and MDC(7-69) seem not be active.;online information:CCL22 entry;PTM:The N-terminal processed forms MDC(3-69); MDC(5-69) and MDC(7-69) are produced by proteolytic cleavage after secretion from monocyte derived dendrocytes.;similarity:Belongs to the intercrine beta (chemokine CC) family.;tissue specificity:Highly expressed in macrophage and in monocyte-derived dendritic cells; and thymus. Also found in lymph node; appendix; activated monocytes; resting and activated macrophages. Lower expression in lung and spleen. Very weak expression in small intestine. In lymph node expressed in a mature subset of Langerhans' cells (CD1a+ and CD83+). Expressed in Langerhans' cell histiocytosis but not in dermatopathic lymphadenopathy. Expressed in atopic dermatitis; allergic contact dermatitis skin; and psoriasis; in both the eptdermis and dermis.;
- Immunogen:
- Synthesized peptide derived from human MDC AA range: 31-80
- Isotype:
- IgG
- Reactivities:
- Human, Rat, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
