Acrogranin rabbit pAb
Product Sizes
50UL
£ POA
ES20288-50UL
100UL
£ POA
ES20288-100UL
About this Product
- SKU:
- ES20288
- Additional Names:
- Granulins (Proepithelin;PEPI) [Cleaved into: Acrogranin; Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Granulin B); Granulin-4 (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)]
- Application:
- Western Blot, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- disease:Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD) [MIM:607485]; also known as tau-negative frontotemporal dementia linked to chromosome 17. Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease.;function:Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4; inhibiting the growth.;function:Granulins have possible cytokine-like activity. They may play a role in inflammation; wound repair; and tissue remodeling.;PTM:Granulins are disulfide bridged.;similarity:Belongs to the granulin family.;tissue specificity:In myelogenous leukemic cell lines of promonocytic; promyelocytic; and proerythroid lineage; in fibroblasts; and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney.;
- Immunogen:
- Synthesized peptide derived from human Acrogranin AA range: 541-590
- Isotype:
- IgG
- Reactivities:
- Human, Rat, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
