Presenilin 2 rabbit pAb
Product Sizes
50UL
£ POA
ES20221-50UL
100UL
£ POA
ES20221-100UL
About this Product
- SKU:
- ES20221
- Additional Names:
- Presenilin-2 (PS-2;EC 3.4.23.-;AD3LP;AD5;E5-1;STM-2) [Cleaved into: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit]
- Application:
- Western Blot, Immunohistochemistry
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase; an enzyme that cleaves APP. Also; it is thought that the presenilins are involved in the cleavage of the Notch receptor such that; they either directly regulate gamma-secretase activity; or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq; Jul 2008];
- Immunogen:
- Synthesized peptide derived from human Presenilin 2 AA range: 270-350
- Isotype:
- IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
