LAT (Phospho Tyr255) rabbit pAb
Product Sizes
50UL
£ POA
ES20193-50UL
100UL
£ POA
ES20193-100UL
About this Product
- SKU:
- ES20193
- Additional Names:
- Linker for activation of T-cells family member 1 (36 kDa phospho-tyrosine adapter protein;pp36;p36-38)
- Application:
- Western Blot, ELISA, Immunohistochemistry
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- function:Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling; both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores; PKC activation; MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1; GRB2; GRAP2; and other signaling molecules.;miscellaneous:Engagement of killer inhibitory receptors (KIR) disrupts the interaction of PLCG1 with LAT and blocks target cell-induced activation of PLC; maybe by inducing the dephosphorylation of LAT.;PTM:Palmitoylation of Cys-26 and Cys-29 is required for raft targeting and efficient phosphorylation.;PTM:Phosphorylated on tyrosines by ZAP-70 upon TCR activation; or by SYK upon other immunoreceptor activation; which leads to the recruitment of multiple signaling molecules. Is one of the most prominently tyrosine-phosphorylated proteins detected following TCR engagement.;subcellular location:Present in lipid rafts.;subunit:When phosphorylated; interacts directly with the PIK3R1 subunit of phosphoinositide 3-kinase and the SH2 domains of GRB2; GRAP; GRAP2; PLCG1 and PLCG2. Interacts indirectly with CBL; SOS; VAV; and LCP2. Interacts with SHB; SKAP2 and CLNK (By similarity). Interacts with FCGR1A.;tissue specificity:Expressed in thymus; T-cells; NK cells; mast cells and; at lower levels; in spleen. Present in T-cells but not B-cells (at protein level).;
- Immunogen:
- Synthesized peptide derived from human LAT (Phospho Tyr255)
- Isotype:
- IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
