FAK (Phospho Ser722) rabbit pAb
Product Sizes
50UL
£ POA
ES20183-50UL
100UL
£ POA
ES20183-100UL
About this Product
- SKU:
- ES20183
- Additional Names:
- Focal adhesion kinase 1 (FADK 1;EC 2.7.10.2;Focal adhesion kinase-related nonkinase;FRNK;Protein phosphatase 1 regulatory subunit 71;PPP1R71;Protein-tyrosine kinase 2;p125FAK;pp125FAK)
- Application:
- Western Blot, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.;domain:The carboxy-terminal region is the site of focal adhesion targeting (FAT) sequence which mediates the localization of FAK1 to focal adhesions.;domain:The first Pro-rich domain interacts with the SH3 domain of CRK-associated substrate (BCAR1) and CASL.;function:Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility; proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking; or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid; or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity.;PTM:Phosphorylated on 6 tyrosine residues upon activation.;similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.;similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. FAK subfamily.;similarity:Contains 1 FERM domain.;similarity:Contains 1 protein kinase domain.;subcellular location:Constituent of focal adhesions.;subunit:Interacts with CAS family members and with GIT1; SORBS1 and BCAR3. Interacts with RGNEF and SHB (By similarity). Interacts with TGFB1I1.;tissue specificity:Expressed in all organs tested; in lymphoid cell lines; but most abundantly in brain.;
- Immunogen:
- Synthesized peptide derived from human FAK (Phospho Ser722)
- Isotype:
- IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
