Rb (Phospho Thr252) rabbit pAb
Product Sizes
50UL
£ POA
ES20170-50UL
100UL
£ POA
ES20170-100UL
About this Product
- SKU:
- ES20170
- Additional Names:
- Retinoblastoma-associated protein (p105-Rb;pRb;Rb;pp110)
- Application:
- Western Blot, ELISA, Immunohistochemistry
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- disease:Defects in RB1 are a cause of bladder cancer [MIM:109800].;disease:Defects in RB1 are a cause of osteogenic sarcoma [MIM:259500].;disease:Defects in RB1 are the cause of childhood cancer retinoblastoma (RB) [MIM:180200]. RB is a congenital malignant tumor that arises from the nuclear layers of the retina. It occurs in about 1:20'000 live births and represents about 2% of childhood malignancies. It is bilateral in about 30% of cases. Although most RB appear sporadically; about 20% are transmitted as an autosomal dominant trait with incomplete penetrance. The diagnosis is usually made before the age of 2 years when strabismus or a gray to yellow reflex from pupil ("cat eye") is investigated.;function:Key regulator of entry into cell division that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated; active form of RB1 interacts with E2F1 and represses its transcription activity; leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and; in particular; that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1; SUV420H1 and SUV420H2; leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. In case of viral infections; interactions with SV40 large T antigen; HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity.;online information:RB1 mutation db;online information:Retinoblastoma protein entry;PTM:Phosphorylated in G1; thereby releasing E2F1 which is then able to activate cell growth. Dephosphorylated at the late M phase. SV40 large T antigen; HPV E7 and adenovirus E1A bind to the underphosphorylated; active form of pRb.;similarity:Belongs to the retinoblastoma protein (RB) family.;subunit:Interacts with ATAD5 (By similarity). The hypophosphorylated form interacts with and sequesters the E2F1 transcription factor. The unphosphorylated form interacts with ARID3B; KDM5A; SUV39H1; MJD2A/JHDM3A and THOC1. Interacts with the N-terminal domain of TAF1. Interacts with AATF; DNMT1; LIN9; LMNA; SUV420H1; SUV420H2; PELP1 and TMPO-alpha. May interact with NDC80. Interacts with EID1 and UBR4. Interacts with ARID4A and KDM5B. Interacts with E4F1. Interacts with adenovirus E1A protein; HPV E7 protein and SV40 large T antigen.;tissue specificity:Expressed in the retina.;
- Immunogen:
- Synthesized peptide derived from human Rb (Phospho Thr252)
- Isotype:
- IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Type:
- Antibodies: Polyclonal Antibody
