ASK1 (Phospho Thr838) rabbit pAb
Product Sizes
50UL
£ POA
ES20167-50UL
100UL
£ POA
ES20167-100UL
About this Product
- SKU:
- ES20167
- Additional Names:
- Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25;Apoptosis signal-regulating kinase 1;ASK-1;MAPK/ERK kinase kinase 5;MEK kinase 5;MEKK 5)
- Application:
- Western Blot, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- catalytic activity:ATP + a protein = ADP + a phosphoprotein.;cofactor:Magnesium.;enzyme regulation:Contains an N-terminal autoinhibitory domain. Activated by phosphorylation at Thr-838; inhibited by phosphorylation at Ser-966 and Ser-1033. Binds to; and stabilizes MAP3K6 and is activated by MAP3K6 by phosphorylation on Thr-838.;function:Component of a protein kinase signal transduction cascade. Phosphorylates and activates MAP2K4 and MAP2K6; which in turn activate the JNK and p38 MAP kinases; respectively. Overexpression induces apoptotic cell death.;induction:By TNF-alpha. Inhibited by HIV-1 Nef.;similarity:Belongs to the protein kinase superfamily.;similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.;similarity:Contains 1 protein kinase domain.;subunit:Homodimer when inactive. Binds both upstream activators and downstream substrates in multimolecular complexes. Associates with and inhibited by HIV-1 Nef. Interacts with DAB2IP and PPM1L.;tissue specificity:Abundantly expressed in heart and pancreas.;
- Immunogen:
- Synthesized peptide derived from human ASK1 (Phospho Thr838)
- Isotype:
- IgG
- Reactivities:
- Human, Rat, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
