Cyclin D1 (Phospho Ser90) rabbit pAb
Product Sizes
50UL
£ POA
ES20156-50UL
100UL
£ POA
ES20156-100UL
About this Product
- SKU:
- ES20156
- Additional Names:
- G1/S-specific cyclin-D1 (B-cell lymphoma 1 protein;BCL-1;BCL-1 oncogene;PRAD1 oncogene)
- Application:
- Western Blot, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- disease:A chromosomal aberration involving CCND1 may be a cause of B-lymphocytic malignancy; particularly mantle-cell lymphoma (MCL). Translocation t(11;14)(q13;q32) with immunoglobulin gene regions. Activation of CCND1 may be oncogenic by directly altering progression through the cell cycle.;disease:A chromosomal aberration involving CCND1 may be a cause of multiple myeloma [MIM:254500]. Translocation t(11;14)(q13;q32) with the IgH locus.;disease:A chromosomal aberration involving CCND1 may be a cause of parathyroid adenomas [MIM:168461]. Translocation t(11;11)(q13;p15) with the parathyroid hormone (PTH) enhancer.;function:Essential for the control of the cell cycle at the G1/S (start) transition.;online information:The Singapore human mutation and polymorphism database;PTM:Following DNA damage it is ubiquitinated by some SCF (SKP1-cullin-F-box) protein ligase complex containing FBXO31. Ubiquitination leads to its degradation and G1 arrest.;PTM:Phosphorylation at Thr-286 by MAP kinases is required for ubiquitination and degradation following DNA damage. It probably plays an essential role for recognition by the FBXO31 component of SCF (SKP1-cullin-F-box) protein ligase complex.;similarity:Belongs to the cyclin family.;similarity:Belongs to the cyclin family. Cyclin D subfamily.;subunit:Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex.;
- Immunogen:
- Synthesized peptide derived from human Cyclin D1 (Phospho Ser90)
- Isotype:
- IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
