RBL2 (Phospho Ser952) rabbit pAb
Product Sizes
50UL
£ POA
ES20153-50UL
100UL
£ POA
ES20153-100UL
About this Product
- SKU:
- ES20153
- Additional Names:
- Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein;p130;Retinoblastoma-related protein 2;RBR-2;pRb2)
- Application:
- Western Blot, ELISA, Immunohistochemistry
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- function:Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and; in particular; that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2; leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation; associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.;miscellaneous:G0-restricted expression.;PTM:During G0 and early G1 phase of the cell cycle; phosphorylated on Ser-639 and on 5 sites within the domain B. Phosphorylation on Ser-672 in G1 leads to its ubiquitin-dependent proteolysis.;similarity:Belongs to the retinoblastoma protein (RB) family.;subunit:Interacts with AATF. Interacts with SUV420H1 and SUV420H2 (By similarity). Component of the DREAM complex (also named LINC complex) at least composed of E2F4; E2F5; LIN9; LIN37; LIN52; LIN54; MYBL1; MYBL2; RBL1; RBL2; RBBP4; TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9; LIN37; LIN52 and LIN54 form a subcomplex that binds to MYBL2. Interacts with RINT1.;
- Immunogen:
- Synthesized peptide derived from human RBL2 (Phospho Ser952)
- Isotype:
- IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
