Chk2 (Phospho Thr432) rabbit pAb
Product Sizes
50UL
£ POA
ES20150-50UL
100UL
£ POA
ES20150-100UL
About this Product
- SKU:
- ES20150
- Additional Names:
- Serine/threonine-protein kinase Chk2 (EC 2.7.11.1;CHK2 checkpoint homolog;Cds1 homolog;Hucds1;hCds1;Checkpoint kinase 2)
- Application:
- Western Blot, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- catalytic activity:ATP + a protein = ADP + a phosphoprotein.;cofactor:Magnesium.;disease:Defects in CHEK2 are associated with Li-Fraumeni syndrome 2 (LFS2) [MIM:609265]; a highly penetrant familial cancer phenotype usually associated with inherited mutations in p53/TP53.;disease:Defects in CHEK2 are found in some patients with osteosarcoma (OSRC) [MIM:259500].;disease:Defects in CHEK2 are found in some patients with prostate cancer (CaP) [MIM:176807].;enzyme regulation:Rapidly phosphorylated on Thr-68 by MLTK in response to DNA damage and to replication block. Kinase activity is also up-regulated by autophosphorylation.;function:Regulates cell cycle checkpoints and apoptosis in response to DNA damage; particularly to DNA double-strand breaks. Inhibits CDC25C phosphatase by phosphorylation on 'Ser-216'; preventing the entry into mitosis. May also play a role in meiosis. Regulates the TP53 tumor suppressor through phosphorylation at 'Thr-18' and 'Ser-20'.;similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHK2 subfamily.;similarity:Contains 1 FHA domain.;similarity:Contains 1 protein kinase domain.;subcellular location:Isoform 10 is present throughout the cell.;tissue specificity:High expression is found in testis; spleen; colon and peripheral blood leukocytes. Low expression is found in other tissues.;
- Immunogen:
- Synthesized peptide derived from human Chk2 (Phospho Thr432)
- Isotype:
- IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
