Histone H2A.Z (Acetyl Lys12) rabbit pAb
Product Sizes
50UL
£ POA
ES20073-50UL
100UL
£ POA
ES20073-100UL
About this Product
- SKU:
- ES20073
- Additional Names:
- Histone H2A.Z (H2A/z)
- Application:
- Western Blot, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- function:Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin; limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation; DNA repair; DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones; also called histone code; and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.;mass spectrometry:Monoisotopic; not modified PubMed:16457589;PTM:Acetylated on Lys-5; Lys-8 and Lys-12 during interphase. Acetylation disappears at mitosis.;PTM:Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression.;PTM:Not phosphorylated.;similarity:Belongs to the histone H2A family.;subunit:The nucleosome is a histone octamer containing two molecules each of H2A; H2B; H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2AFZ forms an heterodimer with H2B. H2AFZ interacts with INCENP.;
- Immunogen:
- Synthesized peptide derived from human Histone H2A.Z (Acetyl Lys12)
- Isotype:
- IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
