GATA-1 (Acetyl Lys312) rabbit pAb
Product Sizes
50UL
£ POA
ES20070-50UL
100UL
£ POA
ES20070-100UL
About this Product
- SKU:
- ES20070
- Additional Names:
- Erythroid transcription factor (Eryf1;GATA-binding factor 1;GATA-1;GF-1;NF-E1 DNA-binding protein)
- Application:
- Western Blot, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- disease:Defects in GATA1 are the cause of X-linked dyserythropoietic anemia and thrombocytopenia (XDAT) [MIM:300367]. XDAT is a disorder characterized by erythrocytes with abnormal size and shape; and paucity of platelets in peripheral blood. The bone marrow contains abundant and abnormally small megakaryocytes.;disease:Defects in GATA1 are the cause of X-linked thrombocytopenia with beta-thalassemia (XLTT) [MIM:314050]; also called thrombocytopenia; platelet dysfunction; hemolysis; and imbalanced globin synthesis. The disease consists of an unusual form of thrombocytopenia with beta-thalassemia. Patients have splenomegaly and petechiae; moderate thrombocytopenia; prolonged bleeding time due to platelet dysfunction; reticulocytosis and unbalanced (hemo)globin chain synthesis resembling that of beta-thalassemia minor.;domain:The two fingers are functionally distinct and cooperate to achieve specific; stable DNA binding. The first finger is necessary only for full specificity and stability of binding; whereas the second one is required for binding.;function:Transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence [AT]GATA[AG] within regulatory regions of globin genes and of other genes expressed in erythroid cells.;PTM:Highly phosphorylated on serine residues. Phosphorylation on Ser-310 is enhanced on erythroid differentiation. Phosphorylation on Ser-142 promotes sumoylation on Lys-137.;PTM:Sumoylation on Lys-137 is enhanced by phosphorylation on Ser-142 and by interaction with PIAS4. Sumoylation by SUMO1 has no effect on transcriptional activity.;similarity:Contains 2 GATA-type zinc fingers.;subunit:Interacts (via the N-terminal zinc finger) with ZFPM1. Interacts with GFI1B. Interacts with PIAS4; the interaction enhances sumoylation and represses the transactivational activity in a sumoylation-independent manner.;tissue specificity:Erythrocytes.;
- Immunogen:
- Synthesized peptide derived from human GATA-1 (Acetyl Lys312)
- Isotype:
- IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
