FoxO1A (Acetyl Lys245) rabbit pAb
Product Sizes
50UL
£ POA
ES20066-50UL
100UL
£ POA
ES20066-100UL
About this Product
- SKU:
- ES20066
- Additional Names:
- Forkhead box protein O1 (Forkhead box protein O1A;Forkhead in rhabdomyosarcoma)
- Application:
- Western Blot, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- disease:Chromosomal aberrations involving FOXO1 are a cause of rhabdomyosarcoma 2 (RMS2) [MIM:268220]; also known as alveolar rhabdomyosarcoma. Translocation (2;13)(q35;q14) with PAX3; translocation t(1;13)(p36;q14) with PAX7. The resulting protein is a transcriptional activator.;function:Transcription factor.;PTM:Phosphorylated by AKT1; insulin-induced (By similarity). IGF1 rapidly induces phosphorylation of Ser-256; Thr-24; and Ser-319. Phosphorylation of Ser-256 decreases DNA-binding activity and promotes the phosphorylation of Thr-24; and Ser-319; permitting phosphorylation of Ser-322 and Ser-325; probably by CK1; leading to nuclear exclusion and loss of function. Phosphorylation of Ser-329 is independent of IGF1 and leads to reduced function. Phosphorylated upon DNA damage; probably by ATM or ATR.;similarity:Contains 1 fork-head DNA-binding domain.;subcellular location:Shuttles between cytoplasm and nucleus.;subunit:Interacts with LRPPRC.;tissue specificity:Ubiquitous.;
- Immunogen:
- Synthesized peptide derived from human FoxO1A (Acetyl Lys245)
- Isotype:
- IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
