Plasma Kallikrein LC (Cleaved-I391) rabbit pAb
Product Sizes
50UL
£ POA
ES20042-50UL
100UL
£ POA
ES20042-100UL
About this Product
- SKU:
- ES20042
- Additional Names:
- Plasma kallikrein (EC 3.4.21.34;Fletcher factor;Kininogenin;Plasma prekallikrein) [Cleaved into: Plasma kallikrein heavy chain; Plasma kallikrein light chain]
- Application:
- Western Blot, ELISA, Immunohistochemistry
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- catalytic activity:Cleaves selectively Arg-|-Xaa and Lys-|-Xaa bonds; including Lys-|-Arg and Arg-|-Ser bonds in (human) kininogen to release bradykinin.;disease:Defects in KLKB1 are the cause of prekallikrein deficiency (PKK deficiency) [MIM:612423]; also called Fletcher factor deficiency. This disorder is a blood coagulation defect.;function:The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates; in a reciprocal reaction; factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.;similarity:Belongs to the peptidase S1 family.;similarity:Belongs to the peptidase S1 family. Plasma kallikrein subfamily.;similarity:Contains 1 peptidase S1 domain.;similarity:Contains 4 apple domains.;subunit:The zymogen is activated by factor XIIa; which cleaves the molecule into a light chain; which contains the active site; and a heavy chain; which associates with HMW kininogen. These chains are linked by one or more disulfide bonds.;
- Immunogen:
- Synthesized peptide derived from human Plasma Kallikrein LC (Cleaved-I391)
- Isotype:
- IgG
- Reactivities:
- Human, Rat, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
