MMP8 (Cleaved-Leu101) rabbit pAb
Product Sizes
50UL
£ POA
ES20030-50UL
100UL
£ POA
ES20030-100UL
About this Product
- SKU:
- ES20030
- Additional Names:
- Neutrophil collagenase (EC 3.4.24.34;Matrix metalloproteinase-8;MMP-8;PMNL collagenase;PMNL-CL)
- Application:
- Western Blot, Immunohistochemistry
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- catalytic activity:Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7; this enzyme cleaves type III collagen more slowly than type I.;cofactor:Binds 2 zinc ions per subunit.;cofactor:Binds 3 calcium ions per subunit.;domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion; thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.;enzyme regulation:Cannot be activated without removal of the activation peptide.;function:Can degrade fibrillar type I; II; and III collagens.;similarity:Belongs to the peptidase M10A family.;similarity:Contains 4 hemopexin-like domains.;subcellular location:Stored in intracellular granules.;tissue specificity:Neutrophils.;
- Immunogen:
- Synthesized peptide derived from human MMP8 (Cleaved-Leu101)
- Isotype:
- IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
