MMP1 (Cleaved-Ile271) rabbit pAb
Product Sizes
50UL
£ POA
ES20022-50UL
100UL
£ POA
ES20022-100UL
About this Product
- SKU:
- ES20022
- Additional Names:
- Interstitial collagenase (EC 3.4.24.7;Fibroblast collagenase;Matrix metalloproteinase-1;MMP-1) [Cleaved into: 22 kDa interstitial collagenase; 27 kDa interstitial collagenase]
- Application:
- Western Blot, ELISA, Immunohistochemistry
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- catalytic activity:Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus; at 775-Gly-|-Ile-776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue.;cofactor:Binds 2 zinc ions per subunit.;cofactor:Binds 4 calcium ions per subunit.;domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion; thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.;domain:There are two distinct domains in this protein; the catalytic N-terminal; and the C-terminal which is involved in substrate specificity and in binding TIMP (tissue inhibitor of metalloproteinases).;enzyme regulation:Can be activated without removal of the activation peptide.;function:Cleaves collagens of types I; II; and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection; interacts and cleaves the secreted viral Tat protein; leading to a decrease in neuronal Tat's mediated neurotoxicity.;online information:Collagenase entry;PTM:Undergoes autolytic cleavage to two major forms (22 kDa and 27 kDa). A minor form (25 kDa) is the glycosylated form of the 22 kDa form. The 27 kDa form has no activity while the 22/25 kDa form can act as activator for collagenase.;similarity:Belongs to the peptidase M10A family.;similarity:Contains 4 hemopexin-like domains.;subunit:Interacts with HIV-1 Tat.;
- Immunogen:
- Synthesized peptide derived from human MMP1 (Cleaved-Ile271)
- Isotype:
- IgG
- Reactivities:
- Human, Rat, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
