C1S (light chain; Cleaved-Ile438) rabbit pAb
Product Sizes
50UL
£ POA
ES19982-50UL
100UL
£ POA
ES19982-100UL
About this Product
- SKU:
- ES19982
- Additional Names:
- Complement C1s subcomponent (EC 3.4.21.42;C1 esterase;Complement component 1 subcomponent s) [Cleaved into: Complement C1s subcomponent heavy chain; Complement C1s subcomponent light chain]
- Application:
- Western Blot, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- catalytic activity:Cleavage of Arg-|-Ala bond in complement component C4 to form C4a and C4b; and Lys(or Arg)-|-Lys bond in complement component C2 to form C2a and C2b: the 'classical' pathway C3 convertase.;disease:Defects in C1S are the cause of selective C1s deficiency [MIM:120580]; that is associated with early onset multiple autoimmune diseases.;enzyme regulation:Inhibited by SERPING1.;function:C1s B chain is a serine protease that combines with C1q and C1s to form C1; the first component of the classical pathway of the complement system. C1r activates C1s so that it can; in turn; activate C2 and C4.;online information:C1S mutation db;PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.;similarity:Belongs to the peptidase S1 family.;similarity:Contains 1 EGF-like domain.;similarity:Contains 1 peptidase S1 domain.;similarity:Contains 2 CUB domains.;similarity:Contains 2 Sushi (CCP/SCR) domains.;subunit:C1 is a calcium-dependent trimolecular complex of C1q; C1r and C1s in the molar ration of 1:2:2. Activated C1s is an disulfide-linked heterodimer of a heavy chain and a light chain.;
- Immunogen:
- Synthesized peptide derived from human C1S (light chain; Cleaved-Ile438)
- Isotype:
- IgG
- Reactivities:
- Human, Rat, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
