Collagen IV α2 (Cleaved-Ser1485) rabbit pAb
Product Sizes
50UL
£ POA
ES19980-50UL
100UL
£ POA
ES19980-100UL
About this Product
- SKU:
- ES19980
- Additional Names:
- Collagen alpha-2(IV) chain [Cleaved into: Canstatin]
- Application:
- Western Blot, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- domain:Alpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus; frequent interruptions of the G-X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix); and a short N-terminal triple-helical 7S domain.;function:Type IV collagen is the major structural component of glomerular basement membranes (GBM); forming a 'chicken-wire' meshwork together with laminins; proteoglycans and entactin/nidogen. Potently inhibits angiogenesis and tumor growth.;PTM:Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.;PTM:The trimeric structure of the NC1 domains may be stabilized by covalent bonds between Lys and Met residues.;PTM:Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these; located in the NC1 domain; are conserved in all known type IV collagens.;similarity:Belongs to the type IV collagen family.;similarity:Contains 1 collagen IV NC1 (C-terminal non-collagenous) domain.;subunit:There are six type IV collagen isoforms; alpha 1(IV)-alpha 6(IV); each of which can form a triple helix structure with 2 other chains to generate type IV collagen network.;
- Immunogen:
- Synthesized peptide derived from human Collagen IV α2 (Cleaved-Ser1485)
- Isotype:
- IgG
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
