Caspase 2 (p12; Cleaved-Ala348) rabbit pAb
Product Sizes
50UL
£ POA
ES19954-50UL
100UL
£ POA
ES19954-100UL
About this Product
- SKU:
- ES19954
- Additional Names:
- Caspase-2 (CASP-2;EC 3.4.22.55;Neural precursor cell expressed developmentally down-regulated protein 2;NEDD-2;Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]
- Application:
- Western Blot, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- alternative products:Isoforms differ in the N- and C-termini;catalytic activity:Strict requirement for an Asp residue at P1; with 316-asp being essential for proteolytic activity and has a preferred cleavage sequence of Val-Asp-Val-Ala-Asp-|-.;function:Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.;PTM:The mature protease can process its own propeptide; but not that of other caspases.;similarity:Belongs to the peptidase C14A family.;similarity:Contains 1 CARD domain.;subunit:Heterotetramer that consists of two anti-parallel arranged heterodimers; each one formed by a p18 subunit and a p12 subunit. Interacts with LRDD.;tissue specificity:Expressed at higher levels in the embryonic lung; liver and kidney than in the heart and brain. In adults; higher level expression is seen in the placenta; lung; kidney; and pancreas than in the heart; brain; liver and skeletal muscle.;
- Immunogen:
- Synthesized peptide derived from human Caspase 2 (p12; Cleaved-Ala348)
- Isotype:
- IgG
- Reactivities:
- Human, Rat, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
