BID (Cleaved-Arg71) rabbit pAb
Product Sizes
50UL
£ POA
ES19950-50UL
100UL
£ POA
ES19950-100UL
About this Product
- SKU:
- ES19950
- Additional Names:
- BH3-interacting domain death agonist (p22 BID;BID) [Cleaved into: BH3-interacting domain death agonist p15 (p15 BID); BH3-interacting domain death agonist p13 (p13 BID); BH3-interacting domain death agonist p11 (p11 BID)]
- Application:
- Western Blot, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- domain:Intact BH3 motif is required by BIK; BID; BAK; BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.;function:The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1; isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2.;PTM:Phosphorylated upon DNA damage; probably by ATM or ATR.;PTM:TNF-alpha induces a caspase-mediated cleavage of p22 BID into a major p15 and minor p13 and p11 products.;subcellular location:A significant proportion of isoform 2 localizes to mitochondria; it may be cleaved constitutively.;subcellular location:Associated with the mitochondrial membrane.;subcellular location:Translocates to mitochondria as an integral membrane protein.;subcellular location:When uncleaved; it is predominantly cytoplasmic.;subunit:Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein Bcl-2.;tissue specificity:Isoforms 2 and 3 are expressed in spleen; bone marrow; cerebral and cerebellar cortex. Isoform 2 is expressed in spleen; pancreas and placenta (at protein level). Isoform 3 is expressed in lung; pancreas and spleen (at protein level). Isoform 4 is expressed in lung and pancreas (at protein level).;
- Immunogen:
- Synthesized peptide derived from human BID (Cleaved-Arg71)
- Isotype:
- IgG
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
