PGCA (Cleaved-Ala17) rabbit pAb
Product Sizes
50UL
£ POA
ES19949-50UL
100UL
£ POA
ES19949-100UL
About this Product
- SKU:
- ES19949
- Additional Names:
- Aggrecan core protein (Cartilage-specific proteoglycan core protein;CSPCP;Chondroitin sulfate proteoglycan core protein 1;Chondroitin sulfate proteoglycan 1) [Cleaved into: Aggrecan core protein 2]
- Application:
- Western Blot, ELISA, Immunohistochemistry
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- alternative products:Additional isoforms seem to exist;developmental stage:Expression was detected in chondrocytes throughout the developing skeleton.;disease:Defects in ACAN are the cause of spondyloepiphyseal dysplasia type Kimberley (SEDK) [MIM:608361]. Spondyloepiphyseal dysplasias are a heterogeneous group of congenital chondrodysplasias that specifically affect epiphyses and vertebrae. The autosomal dominant SEDK is associated with premature degenerative arthropathy.;domain:Two globular domains; G1 and G2; comprise the N-terminus of the proteoglycan; while another globular region; G3; makes up the C-terminus. G1 contains Link domains and thus consists of three disulfide-bonded loop structures designated as the A; B; B' motifs. G2 is similar to G1. The keratan sulfate (KS) and the chondroitin sulfate (CS) attachment domains lie between G2 and G3.;function:This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region.;online information:Aggrecan;PTM:Contains mostly chondroitin sulfate; but also keratan sulfate chains; N-linked and O-linked oligosaccharides. The release of aggrecan fragments from articular cartilage into the synovial fluid at all stages of human osteoarthritis is the result of cleavage by aggrecanase.;similarity:Belongs to the aggrecan/versican proteoglycan family.;similarity:Contains 1 C-type lectin domain.;similarity:Contains 1 EGF-like domain.;similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.;similarity:Contains 1 Sushi (CCP/SCR) domain.;similarity:Contains 4 Link domains.;subunit:Interacts with FBLN1.;tissue specificity:Restricted to cartilages.;
- Immunogen:
- Synthesized peptide derived from human PGCA (Cleaved-Ala17)
- Isotype:
- IgG
- Reactivities:
- Human, Rat
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
