Caspase12 rabbit pAb
Product Sizes
50UL
£ POA
ES1852-50UL
100UL
£ POA
ES1852-100UL
About this Product
- SKU:
- ES1852
- Additional Names:
- CASP12; Inactive caspase-12; CASP-12
- Application:
- Western Blot, Immunohistochemistry, Immunofluorescence, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents; the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However; in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq; Feb 2011];
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human Caspase12. AA range:50-99
- Isotype:
- IgG
- Reactivities:
- Human, Rat, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
